Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation

• Päätekijät: Jordan T. Brooks (Tekijä), Ron J. Keizer (Tekijä), Janel R. Long-Boyle (Tekijä), Sandhya Kharbanda (Tekijä), Christopher C. Dvorak (Tekijä), Brian D. Friend (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Background: With a notably narrow therapeutic window and wide intra- and interindividual pharmacokinetic (PK) variability, initial weight-based dosing along with routine therapeutic drug monitoring of tacrolimus are employed to optimize its clinical utilization. Both supratherapeutic and subtherapeu...