SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson's disease

• Main Authors: Polina Petkova-Kirova (Author), Anastasia Kolchina (Author), Stephan Baas (Author), Gudrun Wagenpfeil (Author), Marcus Michael Unger (Author), Julia Maria Schulze-Hentrich (Author), Rita Bernhardt (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Besides being an essential structural component of plasma membranes and the precursor of many functional compounds and signaling molecules, cholesterol was also proposed to play a role in the etiology and/or manifestation of Parkinson's disease (PD). However, so far systematic investigations on...