SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson's disease

• Prif Awduron: Polina Petkova-Kirova (Awdur), Anastasia Kolchina (Awdur), Stephan Baas (Awdur), Gudrun Wagenpfeil (Awdur), Marcus Michael Unger (Awdur), Julia Maria Schulze-Hentrich (Awdur), Rita Bernhardt (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Besides being an essential structural component of plasma membranes and the precursor of many functional compounds and signaling molecules, cholesterol was also proposed to play a role in the etiology and/or manifestation of Parkinson's disease (PD). However, so far systematic investigations on...