Multifunctional approach with LHRH-mediated PLGA nanoconjugate for site-specific codelivery of curcumin and BCL2 siRNA in mice lung cancer

• Main Authors: Madhuchandra Lahan (Author), Trideep Saikia (Author), Kalpajit Dutta (Author), Rinku Baishya (Author), Alakesh Bharali (Author), Sunayana Baruah (Author), Rituraj Bharadwaj (Author), Subhash Medhi (Author), Bhanu P. Sahu (Author)
• Format: Book
• Published: SpringerOpen, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Lung cancer remains a leading cancer type, but current chemotherapy is limited by issues including poor drug delivery, toxicity, and resistance. To address these challenges, we developed a novel PLGA-PEG-LHRH (PPL) nanoconjugate system for improved drug delivery. Curcumin, known...