Multifunctional approach with LHRH-mediated PLGA nanoconjugate for site-specific codelivery of curcumin and BCL2 siRNA in mice lung cancer

• Hauptverfasser: Madhuchandra Lahan (Verfasst von), Trideep Saikia (Verfasst von), Kalpajit Dutta (Verfasst von), Rinku Baishya (Verfasst von), Alakesh Bharali (Verfasst von), Sunayana Baruah (Verfasst von), Rituraj Bharadwaj (Verfasst von), Subhash Medhi (Verfasst von), Bhanu P. Sahu (Verfasst von)
• Format: Buch
• Veröffentlicht: SpringerOpen, 2024-11-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background Lung cancer remains a leading cancer type, but current chemotherapy is limited by issues including poor drug delivery, toxicity, and resistance. To address these challenges, we developed a novel PLGA-PEG-LHRH (PPL) nanoconjugate system for improved drug delivery. Curcumin, known...