Multifunctional approach with LHRH-mediated PLGA nanoconjugate for site-specific codelivery of curcumin and BCL2 siRNA in mice lung cancer

• Автори: Madhuchandra Lahan (Автор), Trideep Saikia (Автор), Kalpajit Dutta (Автор), Rinku Baishya (Автор), Alakesh Bharali (Автор), Sunayana Baruah (Автор), Rituraj Bharadwaj (Автор), Subhash Medhi (Автор), Bhanu P. Sahu (Автор)
• Формат: Книга
• Опубліковано: SpringerOpen, 2024-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Background Lung cancer remains a leading cancer type, but current chemotherapy is limited by issues including poor drug delivery, toxicity, and resistance. To address these challenges, we developed a novel PLGA-PEG-LHRH (PPL) nanoconjugate system for improved drug delivery. Curcumin, known...