Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice

• Main Authors: Weinstein Michael B (Author), Nalam Roopa L (Author), Agno Julio E (Author), Rajanahally Saneal (Author), Loveland Kate L (Author), Matzuk Martin M (Author), Li Qinglei (Author)
• Format: Book
• Published: BMC, 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Inhibin is a tumor-suppressor and activin antagonist. Inhibin-deficient mice develop gonadal tumors and a cachexia wasting syndrome due to enhanced activin signaling. Because activins signal through SMAD2 and SMAD3 in vitro and loss...