Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice

• Prif Awduron: Weinstein Michael B (Awdur), Nalam Roopa L (Awdur), Agno Julio E (Awdur), Rajanahally Saneal (Awdur), Loveland Kate L (Awdur), Matzuk Martin M (Awdur), Li Qinglei (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: BMC, 2010-06-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Inhibin is a tumor-suppressor and activin antagonist. Inhibin-deficient mice develop gonadal tumors and a cachexia wasting syndrome due to enhanced activin signaling. Because activins signal through SMAD2 and SMAD3 in vitro and loss...