Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice

• Asıl Yazarlar: Weinstein Michael B (Yazar), Nalam Roopa L (Yazar), Agno Julio E (Yazar), Rajanahally Saneal (Yazar), Loveland Kate L (Yazar), Matzuk Martin M (Yazar), Li Qinglei (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: BMC, 2010-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Inhibin is a tumor-suppressor and activin antagonist. Inhibin-deficient mice develop gonadal tumors and a cachexia wasting syndrome due to enhanced activin signaling. Because activins signal through SMAD2 and SMAD3 in vitro and loss...