The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets - improving meta-analysis and prediction of prognosis

• Автори: Pepper Stuart D (Автор), Okoniewski Michal J (Автор), Hey Yvonne (Автор), Smethurst Graeme J (Автор), Sims Andrew H (Автор), Howell Anthony (Автор), Miller Crispin J (Автор), Clarke Robert B (Автор)
• Формат: Книга
• Опубліковано: BMC, 2008-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The number of gene expression studies in the public domain is rapidly increasing, representing a highly valuable resource. However, dataset-specific bias precludes meta-analysis at the raw transcript level, even when the RNA is from...