METTL14-mediated m6A modification enhances USP22-ERα axis to drive breast cancer malignancy

• Main Authors: Xuefen Zhuang (Author), Shusha Yin (Author), Ji Cheng (Author), Wenshuang Sun (Author), Zesen Fang (Author), Yujie Xiang (Author), E.-ying Peng (Author), Yu Yao (Author), Yuting Li (Author), Xiaoyue He (Author), Li Lu (Author), Yuanfei Deng (Author), Hongbiao Huang (Author), Gengxi Cai (Author), Yuning Liao (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The abundance and activity of estrogen receptor alpha (ERα) are tightly regulated by ubiquitin-specific peptidase 22 (USP22) during the progression of breast cancer (BCa). However, the post-transcriptional modifications on the USP22-ERα axis remain elusive. N6-methyladenosine (m6A) is critical to mo...