METTL14-mediated m6A modification enhances USP22-ERα axis to drive breast cancer malignancy

• Glavni autori: Xuefen Zhuang (Autor), Shusha Yin (Autor), Ji Cheng (Autor), Wenshuang Sun (Autor), Zesen Fang (Autor), Yujie Xiang (Autor), E.-ying Peng (Autor), Yu Yao (Autor), Yuting Li (Autor), Xiaoyue He (Autor), Li Lu (Autor), Yuanfei Deng (Autor), Hongbiao Huang (Autor), Gengxi Cai (Autor), Yuning Liao (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2024-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

The abundance and activity of estrogen receptor alpha (ERα) are tightly regulated by ubiquitin-specific peptidase 22 (USP22) during the progression of breast cancer (BCa). However, the post-transcriptional modifications on the USP22-ERα axis remain elusive. N6-methyladenosine (m6A) is critical to mo...