Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer

• Hauptverfasser: Qiuyuan Wen (Verfasst von), Yuting Zhan (Verfasst von), Hongmei Zheng (Verfasst von), Hongjing Zang (Verfasst von), Jiadi Luo (Verfasst von), Yuting Zhang (Verfasst von), Weiyuan Wang (Verfasst von), Juan Feng (Verfasst von), Junmi Lu (Verfasst von), Lingjiao Chen (Verfasst von), Songqing Fan (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2019-10-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background Mcl-1, an anti-apoptotic member of bcl-2 family, together with cleaved poly (ADC-ribose) polymerase (c-PARP) can serve as a marker of cell apoptosis. Previously we reported that treatment of Mnk inhibitor CGP57380 resulted in decreased Mcl-1 expression while increased c-PARP expr...