Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer

• Main Authors: Qiuyuan Wen (Author), Yuting Zhan (Author), Hongmei Zheng (Author), Hongjing Zang (Author), Jiadi Luo (Author), Yuting Zhang (Author), Weiyuan Wang (Author), Juan Feng (Author), Junmi Lu (Author), Lingjiao Chen (Author), Songqing Fan (Author)
• Format: Knjiga
• Izdano: BMC, 2019-10-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Background Mcl-1, an anti-apoptotic member of bcl-2 family, together with cleaved poly (ADC-ribose) polymerase (c-PARP) can serve as a marker of cell apoptosis. Previously we reported that treatment of Mnk inhibitor CGP57380 resulted in decreased Mcl-1 expression while increased c-PARP expr...