Co-Delivery of siRNA and Chemotherapeutic Drug Using 2C5 Antibody-Targeted Dendrimer-Based Mixed Micelles for Multidrug Resistant Cancers

• Principais autores: Satya Siva Kishan Yalamarty (Autor), Nina Filipczak (Autor), Xiang Li (Autor), Tanvi Vinod Pathrikar (Autor), Colin Cotter (Autor), Vladimir P. Torchilin (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Multidrug resistance (MDR) observed in tumors significantly hinders the efficacy of chemotherapy. Downregulation of efflux proteins, such as P-glycoprotein (P-gp), using small interfering RNA (siRNA) can be an effective way to minimize the resistance in tumors. In this study, monoclonal antibody 2C5...