Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement

• Główni autorzy: Poovizhi Ponnammal (Autor), Parijat Kanaujia (Autor), Yin Yani (Autor), Wai Kiong Ng (Autor), Reginald B. H. Tan (Autor)
• Format: Książka
• Wydane: MDPI AG, 2018-03-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and Hydroxypropyl Cellulose (HPC), at a drug loading of 10%...