A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments

• Main Authors: Xiao-Hua Li (Author), Wei-Wei Pang (Author), Yue Zhang (Author), Dan-Yang Liu (Author), Qiao-Rong Yi (Author), Ning Wang (Author), Fu-Rong Zhang (Author), Yun Deng (Author), Xiang-Ding Chen (Author), Jonathan Greenbaum (Author), Hong-Mei Xiao (Author), Hong-Wen Deng (Author), Li-Jun Tan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Lipid pathways have been implicated in the pathogenesis of osteoporosis (OP). Lipid-lowering drugs may be used to prevent and treat OP. However, the causal interpretation of results from traditional observational designs is controversial by confounding. We aimed to investigate the causal...