Co-inhibition of Angiotensin II Receptor and Endothelin-1 Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice

• Main Authors: Yoon-Kyung Chang (Author), Hyunsu Choi (Author), Jin Young Jeong (Author), Ki-Ryang Na (Author), Kang Wook Lee (Author), Dae Eun Choi (Author)
• Format: Book
• Published: Karger Publishers, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Both endothelin-1 (ET-1) and the renin-angiotensin system (RAS) may play important roles in renal fibrosis in the obstructed kidney. However, there have been few clear demonstrations of a relationship between their activation and additive or synergistic roles in renal fibrosis. We i...