Effective delivery of osteopontin small interference RNA using exosomes suppresses liver fibrosis via TGF-β1 signaling

• Main Authors: Min Tang (Author), Cheng Guo (Author), Mengxue Sun (Author), Hao Zhou (Author), Xin Peng (Author), Jianli Dai (Author), Qin Ding (Author), Ying Wang (Author), Changqing Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective and aims: Osteopontin (OPN), an oxidant stress sensitive cytokine, plays a central role in liver fibrosis. While OPN expression can be reduced by small interfering RNA (siRNA), the challenge to deliver siRNA safely and effectively into liver remains unresolved. Exosomes are promising natur...