Effective delivery of osteopontin small interference RNA using exosomes suppresses liver fibrosis via TGF-β1 signaling

• Главные авторы: Min Tang (Автор), Cheng Guo (Автор), Mengxue Sun (Автор), Hao Zhou (Автор), Xin Peng (Автор), Jianli Dai (Автор), Qin Ding (Автор), Ying Wang (Автор), Changqing Yang (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Предметы: article
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Objective and aims: Osteopontin (OPN), an oxidant stress sensitive cytokine, plays a central role in liver fibrosis. While OPN expression can be reduced by small interfering RNA (siRNA), the challenge to deliver siRNA safely and effectively into liver remains unresolved. Exosomes are promising natur...