SDF-1/CXCR4 Signaling Maintains Stemness Signature in Mouse Neural Stem/Progenitor Cells

• Main Authors: Shih-Yin Ho (Author), Thai-Yen Ling (Author), Hsing-Yu Lin (Author), Jeffrey Tsai-Jui Liou (Author), Fei-Chih Liu (Author), I-Chun Chen (Author), Sue-Wei Lee (Author), Yu Hsu (Author), Dar-Ming Lai (Author), Horng-Huei Liou (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SDF-1 and its primary receptor, CXCR4, are highly expressed in the embryonic central nervous system (CNS) and play a crucial role in brain architecture. Loss of SDF-1/CXCR4 signaling causes abnormal development of neural stem/progenitor cells (NSCs/NPCs) in the cerebellum, hippocampus, and cortex. H...