A VEGFB-Based Peptidomimetic Inhibits VEGFR2-Mediated PI3K/Akt/mTOR and PLCγ/ERK Signaling and Elicits Apoptotic, Antiangiogenic, and Antitumor Activities

• Main Authors: Mohadeseh Namjoo (Author), Hossein Ghafouri (Author), Elham Assareh (Author), Amir Reza Aref (Author), Ebrahim Mostafavi (Author), Ali Hamrahi Mohsen (Author), Saeed Balalaie (Author), Sylvain Broussy (Author), S. Mohsen Asghari (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular endothelial growth factor receptor 2 (VEGFR2) mediates VEGFA signaling mainly through the PI3K/AKT/mTOR and PLCγ/ERK1/2 pathways. Here we unveil a peptidomimetic (VGB3) based on the interaction between VEGFB and VEGFR1 that unexpectedly binds and neutralizes VEGFR2. Investigation of the cyc...