A VEGFB-Based Peptidomimetic Inhibits VEGFR2-Mediated PI3K/Akt/mTOR and PLCγ/ERK Signaling and Elicits Apoptotic, Antiangiogenic, and Antitumor Activities

• Hoofdauteurs: Mohadeseh Namjoo (Auteur), Hossein Ghafouri (Auteur), Elham Assareh (Auteur), Amir Reza Aref (Auteur), Ebrahim Mostafavi (Auteur), Ali Hamrahi Mohsen (Auteur), Saeed Balalaie (Auteur), Sylvain Broussy (Auteur), S. Mohsen Asghari (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Vascular endothelial growth factor receptor 2 (VEGFR2) mediates VEGFA signaling mainly through the PI3K/AKT/mTOR and PLCγ/ERK1/2 pathways. Here we unveil a peptidomimetic (VGB3) based on the interaction between VEGFB and VEGFR1 that unexpectedly binds and neutralizes VEGFR2. Investigation of the cyc...