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Assessment of H3K27me3 immunohistochemistry and combination of NF1 and p16 deletions by fluorescence in situ hybridization in the differential diagnosis of malignant peripheral nerve sheath tumor and its histological mimics

Abstract Background A definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is challenging, especially in cases without neurofibromatosis 1 (NF1), because MPNST lacks specific markers on immunohistochemistry (IHC). Methods We performed IHC for histone 3 trimethylated on lysine 27 (...

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Main Authors: Shintaro Sugita (Author), Tomoyuki Aoyama (Author), Makoto Emori (Author), Tomomi Kido (Author), Tomoko Takenami (Author), Kodai Sakuraba (Author), Kotomi Terai (Author), Taro Sugawara (Author), Mitsuhiro Tsujiwaki (Author), Tadashi Hasegawa (Author)
Format: Book
Published: BMC, 2021-08-01T00:00:00Z.
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