Development of (4-Phenylamino)quinazoline Alkylthiourea Derivatives as Novel NF-κB Inhibitors

• Egile Nagusiak: Sarah S. Darwish (Egilea), Po-Jen Chen (Egilea), Mostafa M. Hamed (Egilea), Reem A. Wagdy (Egilea), Shun-Hua Chen (Egilea), Ashraf H. Abadi (Egilea), Mohammad Abdel-Halim (Egilea), Tsong-Long Hwang (Egilea), Matthias Engel (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

For many inflammatory diseases, new effective drugs with fewer side effects are needed. While it appears promising to target the activation of the central pro-inflammatory transcription factor NF-κB, many previously discovered agents suffered from cytotoxicity. In this study, new alkylthiourea quina...