Development of (4-Phenylamino)quinazoline Alkylthiourea Derivatives as Novel NF-κB Inhibitors

• Main Authors: Sarah S. Darwish (Author), Po-Jen Chen (Author), Mostafa M. Hamed (Author), Reem A. Wagdy (Author), Shun-Hua Chen (Author), Ashraf H. Abadi (Author), Mohammad Abdel-Halim (Author), Tsong-Long Hwang (Author), Matthias Engel (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For many inflammatory diseases, new effective drugs with fewer side effects are needed. While it appears promising to target the activation of the central pro-inflammatory transcription factor NF-κB, many previously discovered agents suffered from cytotoxicity. In this study, new alkylthiourea quina...