β-Hydroxybutyrate enhances the cytotoxic effect of cisplatin via the inhibition of HDAC/survivin axis in human hepatocellular carcinoma cells

• প্রধান লেখক: Daisuke Mikami (লেখক), Mamiko Kobayashi (লেখক), Junsuke Uwada (লেখক), Takashi Yazawa (লেখক), Kazuko Kamiyama (লেখক), Kazuhisa Nishimori (লেখক), Yudai Nishikawa (লেখক), Sho Nishikawa (লেখক), Seiji Yokoi (লেখক), Takanobu Taniguchi (লেখক), Masayuki Iwano (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2020-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Ketone bodies, including acetoacetate and β-hydroxybutyrate (βOHB), are produced from acetyl coenzyme A in the liver and then secreted into the blood. These molecules are a source of energy for peripheral tissues during exercise or fasting. βOHB has been reported to inhibit histone deacetylases (HDA...