β-Hydroxybutyrate enhances the cytotoxic effect of cisplatin via the inhibition of HDAC/survivin axis in human hepatocellular carcinoma cells

• Main Authors: Daisuke Mikami (Author), Mamiko Kobayashi (Author), Junsuke Uwada (Author), Takashi Yazawa (Author), Kazuko Kamiyama (Author), Kazuhisa Nishimori (Author), Yudai Nishikawa (Author), Sho Nishikawa (Author), Seiji Yokoi (Author), Takanobu Taniguchi (Author), Masayuki Iwano (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ketone bodies, including acetoacetate and β-hydroxybutyrate (βOHB), are produced from acetyl coenzyme A in the liver and then secreted into the blood. These molecules are a source of energy for peripheral tissues during exercise or fasting. βOHB has been reported to inhibit histone deacetylases (HDA...