Method development for the quantitative determination of captopril from Caco-2 cell monolayers by using LC-MS/MS

• Main Authors: Liliya Logoyda (Author), Marjan Piponski (Author), Sergiy Kovalenko (Author), Olha Denefil (Author), Olha Dutchak (Author), Yuriy Soroka (Author), Svitlana Pidruchna (Author), Dariya Popovych (Author), Oleksandr Susla (Author)
• Format: Book
• Published: Pensoft Publishers, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim. Caco-2 cells are a human colon epithelial cancer cell line used as a model of human intestinal absorption of drugs and other compounds. Although compounds were used in the original Caco-2 cells monolayer assays, compounds have been replaced in most laboratories by the use of liquid chromatograp...