Ortho-nitrobenzyl derivatives as potential anti-schistosomal agents

• Autores principales: Marcela Silva Lopes (Autor), Brian Michio Suzuki (Autor), Glaécia Aparecida do Nascimento Pereira (Autor), Alexandra Christina Probst (Autor), Rafaela Salgado Ferreira (Autor), Júlia Teixeira de Oliveira (Autor), Kimberly Brito Tecchio (Autor), Fabio Vieira dos Santos (Autor), Conor Robert Caffrey (Autor), Renata Barbosa de Oliveira (Autor)
• Formato: Libro
• Publicado: Universidade de São Paulo, 2018-07-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

ABSTRACT In the search for new anti-schistosomal agents, a series of fifteen ortho-nitrobenzyl derivatives was assayed in vitro against both the schistosomulum (somule) and adult forms of Schistosoma mansoni. Compounds 8 and 12 showed significant activity against somules at low micromolar concentrat...