Ortho-nitrobenzyl derivatives as potential anti-schistosomal agents

• मुख्य लेखकों: Marcela Silva Lopes (लेखक), Brian Michio Suzuki (लेखक), Glaécia Aparecida do Nascimento Pereira (लेखक), Alexandra Christina Probst (लेखक), Rafaela Salgado Ferreira (लेखक), Júlia Teixeira de Oliveira (लेखक), Kimberly Brito Tecchio (लेखक), Fabio Vieira dos Santos (लेखक), Conor Robert Caffrey (लेखक), Renata Barbosa de Oliveira (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Universidade de São Paulo, 2018-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

ABSTRACT In the search for new anti-schistosomal agents, a series of fifteen ortho-nitrobenzyl derivatives was assayed in vitro against both the schistosomulum (somule) and adult forms of Schistosoma mansoni. Compounds 8 and 12 showed significant activity against somules at low micromolar concentrat...