An Exploratory Pilot Study of Changes in Global DNA Methylation in Patients Undergoing Major Breast Surgery Under Opioid-Based General Anesthesia

• Main Authors: Francesca Felicia Caputi (Author), Lucia Carboni (Author), Laura Rullo (Author), Irene Alessandrini (Author), Eleonora Balzani (Author), Rita Maria Melotti (Author), Patrizia Romualdi (Author), Sanzio Candeletti (Author), Andrea Fanelli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to investigate DNA methylation levels in patients undergoing major breast surgery under opioid-based general anesthesia. Blood samples were collected from eleven enrolled patients, before, during and after anesthesia. PBMC were isolated and global DNA methylation levels as well as D...