Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD

• Main Authors: Sofie Vets (Author), Jan De Rijck (Author), Christian Brendel (Author), Manuel Grez (Author), Frederic Bushman (Author), Zeger Debyser (Author), Rik Gijsbers (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retrovirus-based vectors are commonly used as delivery vehicles to correct genetic diseases because of their ability to integrate new sequences stably. However, adverse events in which vector integration activates proto-oncogenes, leading to clonal expansion and leukemogenesis hamper their applicati...