Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD

• Váldodahkkit: Sofie Vets (Dahkki), Jan De Rijck (Dahkki), Christian Brendel (Dahkki), Manuel Grez (Dahkki), Frederic Bushman (Dahkki), Zeger Debyser (Dahkki), Rik Gijsbers (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2013-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Retrovirus-based vectors are commonly used as delivery vehicles to correct genetic diseases because of their ability to integrate new sequences stably. However, adverse events in which vector integration activates proto-oncogenes, leading to clonal expansion and leukemogenesis hamper their applicati...