Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD

• मुख्य लेखकों: Sofie Vets (लेखक), Jan De Rijck (लेखक), Christian Brendel (लेखक), Manuel Grez (लेखक), Frederic Bushman (लेखक), Zeger Debyser (लेखक), Rik Gijsbers (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2013-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Retrovirus-based vectors are commonly used as delivery vehicles to correct genetic diseases because of their ability to integrate new sequences stably. However, adverse events in which vector integration activates proto-oncogenes, leading to clonal expansion and leukemogenesis hamper their applicati...