Simulating realistic patient profiles from pharmacokinetic models by a machine learning postprocessing correction of residual variability

• Main Authors: Christos Kaikousidis (Author), Robert R. Bies (Author), Aristides Dokoumetzidis (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2024-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract We address the problem of model misspecification in population pharmacokinetics (PopPK), by modeling residual unexplained variability (RUV) by machine learning (ML) methods in a postprocessing step after conventional model building. The practical purpose of the method is the generation of r...