Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia

• Hoofdauteurs: Xue Bai (Auteur), Jianxin Yang (Auteur), Guiqin Liu (Auteur), Junbo Zhu (Auteur), Qian Wang (Auteur), Wenqi Gu (Auteur), Linli La (Auteur), Xiangyang Li (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Hypoxia, an essential feature of high-altitude environments, has a significant effect on drug metabolism. The hypoxia-gut microbiota-CYP450/drug transporter axis is emerging as a vital factor in drug metabolism. However, the mechanisms through which the gut microbiota mediates the regulation of CYP4...