Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia

• Main Authors: Xue Bai (Author), Jianxin Yang (Author), Guiqin Liu (Author), Junbo Zhu (Author), Qian Wang (Author), Wenqi Gu (Author), Linli La (Author), Xiangyang Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia, an essential feature of high-altitude environments, has a significant effect on drug metabolism. The hypoxia-gut microbiota-CYP450/drug transporter axis is emerging as a vital factor in drug metabolism. However, the mechanisms through which the gut microbiota mediates the regulation of CYP4...