Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia

• Váldodahkkit: Xue Bai (Dahkki), Jianxin Yang (Dahkki), Guiqin Liu (Dahkki), Junbo Zhu (Dahkki), Qian Wang (Dahkki), Wenqi Gu (Dahkki), Linli La (Dahkki), Xiangyang Li (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Hypoxia, an essential feature of high-altitude environments, has a significant effect on drug metabolism. The hypoxia-gut microbiota-CYP450/drug transporter axis is emerging as a vital factor in drug metabolism. However, the mechanisms through which the gut microbiota mediates the regulation of CYP4...