Mouse models for V103I and I251L gain of function variants of the human MC4R display decreased adiposity but are not protected against a hypercaloric diet

Objective: The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor that plays major roles in the central control of energy balance. Loss-of-function mutations of MC4R constitute the most common monogenic cause of early-onset extreme obesity in humans, whereas gain-of-function mutations ap...

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Váldodahkkit: Daniela Rojo (Dahkki), Clara McCarthy (Dahkki), Jesica Raingo (Dahkki), Marcelo Rubinstein (Dahkki)
Materiálatiipa: Girji
Almmustuhtton: Elsevier, 2020-12-01T00:00:00Z.
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