Mouse models for V103I and I251L gain of function variants of the human MC4R display decreased adiposity but are not protected against a hypercaloric diet

• 主要な著者: Daniela Rojo (著者), Clara McCarthy (著者), Jesica Raingo (著者), Marcelo Rubinstein (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2020-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor that plays major roles in the central control of energy balance. Loss-of-function mutations of MC4R constitute the most common monogenic cause of early-onset extreme obesity in humans, whereas gain-of-function mutations ap...