Pharmacokinetic/pharmacodynamic modeling of cortical dopamine concentrations after quetiapine lipid core nanocapsules administration to schizophrenia phenotyped rats

• Main Authors: Bruna Bernar Dias (Author), Fernando Carreño (Author), Victória Etges Helfer (Author), Laura Ben Olivo (Author), Keli Jaqueline Staudt (Author), Karina Paese (Author), Fabiano Barreto (Author), Fabíola Schons Meyer (Author), Ana Paula Herrmann (Author), Sílvia Stanisçuaski Guterres (Author), Stela Maris Kuze Rates (Author), Bibiana Verlindo deAraújo (Author), Iñaki F. Trocóniz (Author), Teresa Dalla Costa (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Schizophrenia (SCZ) response to pharmacological treatment is highly variable. Quetiapine (QTP) administered as QTP lipid core nanocapsules (QLNC) has been shown to modulate drug delivery to the brain of SCZ phenotyped rats (SPR). In the present study, we describe the brain concentration-eff...