Pharmacokinetic/pharmacodynamic modeling of cortical dopamine concentrations after quetiapine lipid core nanocapsules administration to schizophrenia phenotyped rats

• Главные авторы: Bruna Bernar Dias (Автор), Fernando Carreño (Автор), Victória Etges Helfer (Автор), Laura Ben Olivo (Автор), Keli Jaqueline Staudt (Автор), Karina Paese (Автор), Fabiano Barreto (Автор), Fabíola Schons Meyer (Автор), Ana Paula Herrmann (Автор), Sílvia Stanisçuaski Guterres (Автор), Stela Maris Kuze Rates (Автор), Bibiana Verlindo deAraújo (Автор), Iñaki F. Trocóniz (Автор), Teresa Dalla Costa (Автор)
• Формат: ‌
• Опубликовано: Wiley, 2024-04-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Abstract Schizophrenia (SCZ) response to pharmacological treatment is highly variable. Quetiapine (QTP) administered as QTP lipid core nanocapsules (QLNC) has been shown to modulate drug delivery to the brain of SCZ phenotyped rats (SPR). In the present study, we describe the brain concentration-eff...