Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice

• Główni autorzy: Maximilian Kleinert (Autor), Petra Kotzbeck (Autor), Thomas Altendorfer-Kroath (Autor), Thomas Birngruber (Autor), Matthias H. Tschöp (Autor), Christoffer Clemmensen (Autor)
• Format: Książka
• Wydane: Elsevier, 2018-07-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Objective: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks. One prevailing theory is that impaired transport of leptin across the blood-brain barrier (BBB) represents a mol...