Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice

• Main Authors: Maximilian Kleinert (Author), Petra Kotzbeck (Author), Thomas Altendorfer-Kroath (Author), Thomas Birngruber (Author), Matthias H. Tschöp (Author), Christoffer Clemmensen (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks. One prevailing theory is that impaired transport of leptin across the blood-brain barrier (BBB) represents a mol...