Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice

• मुख्य लेखकों: Maximilian Kleinert (लेखक), Petra Kotzbeck (लेखक), Thomas Altendorfer-Kroath (लेखक), Thomas Birngruber (लेखक), Matthias H. Tschöp (लेखक), Christoffer Clemmensen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2018-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks. One prevailing theory is that impaired transport of leptin across the blood-brain barrier (BBB) represents a mol...