Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms

• প্রধান লেখক: Payal Rana (লেখক), Michael D. Aleo (লেখক), Xuerong Wen (লেখক), Stephen Kogut (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2021-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI, especially in idiosyncratic liver injury. This study examined liver injury re...