Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules

• Main Authors: Yan-Chuang Han (Author), Yoon Lim (Author), Michael D. Duffieldl (Author), Hua Li (Author), Jia Liu (Author), Nimshitha Pavathuparambil Abdul Manaph (Author), Miao Yang (Author), Damien J. Keating (Author), Xin-Fu Zhou (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although it is possible to generate neural stem cells (NSC) from somatic cells by reprogramming technologies with transcription factors, clinical utilization of patient-specific NSC for the treatment of human diseases remains elusive. The risk hurdles are associated with viral transduction vectors i...