Predicting and designing therapeutics against the Nipah virus.

• Main Authors: Neeladri Sen (Author), Tejashree Rajaram Kanitkar (Author), Ankit Animesh Roy (Author), Neelesh Soni (Author), Kaustubh Amritkar (Author), Shreyas Supekar (Author), Sanjana Nair (Author), Gulzar Singh (Author), M S Madhusudhan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite Nipah virus outbreaks having high mortality rates (>70% in Southeast Asia), there are no licensed drugs against it. In this study, we have considered all 9 Nipah proteins as potential therapeutic targets and computationally identified 4 putative peptide inhibitors (against G, F and M prot...