The Multistage Antimalarial Compound Calxinin Perturbates <i>P. falciparum</i> Ca²⁺ Homeostasis by Targeting a Unique Ion Channel

• Main Authors: Yash Gupta (Author), Neha Sharma (Author), Snigdha Singh (Author), Jesus G. Romero (Author), Vinoth Rajendran (Author), Reagan M. Mogire (Author), Mohammad Kashif (Author), Jordan Beach (Author), Walter Jeske (Author), Poonam (Author), Bernhards R. Ogutu (Author), Stefan M. Kanzok (Author), Hoseah M. Akala (Author), Jennifer Legac (Author), Philip J. Rosenthal (Author), David J. Rademacher (Author), Ravi Durvasula (Author), Agam P. Singh (Author), Brijesh Rathi (Author), Prakasha Kempaiah (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Malaria elimination urgently needs novel antimalarial therapies that transcend resistance, toxicity, and high costs. Our multicentric international collaborative team focuses on developing multistage antimalarials that exhibit novel mechanisms of action. Here, we describe the design, synthesis, and...