Nitric Oxide Resistance in <i>Leishmania</i> (<i>Viannia</i>) <i>braziliensis</i> Involves Regulation of Glucose Consumption, Glutathione Metabolism and Abundance of Pentose Phosphate Pathway Enzymes

• Main Authors: Nathalia Pinho (Author), Ana Cristina Bombaça (Author), Jacek R. Wiśniewski (Author), Geovane Dias-Lopes (Author), Leonardo Saboia-Vahia (Author), Elisa Cupolillo (Author), José Batista de Jesus (Author), Roque P. de Almeida (Author), Gabriel Padrón (Author), Rubem Menna-Barreto (Author), Patricia Cuervo (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In American Tegumentary Leishmaniasis production of cytokines, reactive oxygen species and nitric oxide (NO) by host macrophages normally lead to parasite death. However, some <i>Leishmania braziliensis</i> strains exhibit natural NO resistance. NO-resistant strains cause more lesions an...