Zolpidem Activation of Alpha 1-Containing GABAA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons

• Main Authors: Elena Neumann (Author), Uwe Rudolph (Author), Daniel E. Knutson (Author), Guanguan Li (Author), James M. Cook (Author), Harald Hentschke (Author), Bernd Antkowiak (Author), Berthold Drexler (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: High frequency neuronal activity in the cerebral cortex can be induced by noxious stimulation during surgery, brain injury or poisoning. In this scenario, it is essential to block cortical hyperactivity to protect the brain against damage, e.g., by using drugs that act as positive allo...