G2/M Checkpoint Abrogation With Selective Inhibitors Results in Increased Chromatid Breaks and Radiosensitization of 82-6 hTERT and RPE Human Cells

• Main Authors: Aggeliki Nikolakopoulou (Author), Aashish Soni (Author), Martha Habibi (Author), Pantelis Karaiskos (Author), Gabriel Pantelias (Author), Georgia I. Terzoudi (Author), George Iliakis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While technological advances in radiation oncology have led to a more precise delivery of radiation dose and a decreased risk of side effects, there is still a need to better understand the mechanisms underlying DNA damage response (DDR) at the DNA and cytogenetic levels, and to overcome tumor resis...