Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior

• المؤلفون الرئيسيون: Sébastien Moreno (مؤلف), Christelle M. Devader (مؤلف), Mariel Pietri (مؤلف), Marc Borsotto (مؤلف), Catherine Heurteaux (مؤلف), Jean Mazella (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The background potassium channel TREK-1 has been shown to be a potent target for depression treatment. Indeed, deletion of this channel in mice resulted in a depression resistant phenotype. The association of TREK-1 with the sorting protein sortilin prompted us to investigate the behavior of mice de...