Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior

• Main Authors: Sébastien Moreno (Author), Christelle M. Devader (Author), Mariel Pietri (Author), Marc Borsotto (Author), Catherine Heurteaux (Author), Jean Mazella (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The background potassium channel TREK-1 has been shown to be a potent target for depression treatment. Indeed, deletion of this channel in mice resulted in a depression resistant phenotype. The association of TREK-1 with the sorting protein sortilin prompted us to investigate the behavior of mice de...