Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior

• Principais autores: Sébastien Moreno (Autor), Christelle M. Devader (Autor), Mariel Pietri (Autor), Marc Borsotto (Autor), Catherine Heurteaux (Autor), Jean Mazella (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The background potassium channel TREK-1 has been shown to be a potent target for depression treatment. Indeed, deletion of this channel in mice resulted in a depression resistant phenotype. The association of TREK-1 with the sorting protein sortilin prompted us to investigate the behavior of mice de...